Three bright dots in a nucleus of a cell may be a signal of tissue anomalies (congenital or acquired), benign or malignant that otherwise escape a diagnosis. The technique FISH (use of DNA probes binding to specific sites) is relatively simple. What is NOT is the selection of the ideal (most informative) FISH probe. This in turn reflects the clinical cleverness and experience of the user – those who see signs (have open eyes) and understand signals (the meaning of signs) combined with experience and knowledge can best select the potentially most informative FISH probe.
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