Lip, Oral, Genital, Peri-anal Melanic Spots

The presence of such signs signal a possible intestinal hamartomatous polyposis and high cancer risk syndrome. The most common name is Peutz-Jeghers syndrome. Vice versa, a family history of cancer of the breast, ovary, stomach, small intestine, pancreas, and of other kinds should trigger a clinical search for melanic spots on the lips, oral cavity, vagina, genital and peri-anal areas.