Pearl – Diagnosis – Synthesis – a Process and Two Perspectives


The process of the synthesis of a diagnosis starts with the gathering of signs inclusive from the anamnesis, parental reproductive histories, family history of genomic and social relatives, and other ecologic (environmental) factors that may pose a risk to the homeostasis (health) of the patient.

The interpretation of signs as signals is followed by their groupings (clusters or syndromes) that may reflect shared mechanisms and causes (etiology, pathogenesis). The synthesis of a hypothetical diagnosis seeks to formulate the most likely cause or causes (etiology) and altered mechanisms (homeostasis) following which an expanded confirmatory search starts generally referred to as differential diagnosis. Two examples follow: