UKRAINIAN CHILDREN WITH DISABILITIES NEED HELP!

ONGOING WAR IN UKRAINE
Our priorities must respond to the threat posed by Russia to Ukrainian children in particular those
with developmental disabilities. Please follow our postings and appeals for assistance.

Pearls – Signs Signals – Objective Subjective

Virtually no SIGN represents a specific SIGNAL.

A group of SIGNS may be interpreted as a single or as multiple SIGNALS.

A SIGN is inherently objective in contrast to signals which are hypothetical interpretations.

A SIGNAL may point to a particular or multiple pathogeneses pathways and etiologies.

Pathogenesis (expression of an etiology) can reflect a variety of causes (etiologies).

Etiology can manifest in a variety of clusters of SIGNS (clinical variability).

Etiology can impact diverse patho-genesis pathways causing diverse signals (pleiotropism).

Etiology is generally categorized as Mendelian (single gene mutations) – cytogenetic – environmental or teratogenic if impacting development – and multifactorial.