Developmental (morphogenetic) Field (DF)

Based on the pioneering original article “DEVELOPMENTAL FIELD” (DF) by
J. M. Opitz (J. Pediatr. 1982 Nov; 101 (5):805-9)

W. Wertelecki, M.D.

The fundamental arguments sustaining the DF concept are:
– DF manifest in specific spatial and chronology patterns (embryogenesis,  fetogenesis).
– DF emerge during blastogenesis, among the first is the body axis (e.g. neural tube).
Blastopahties are among the earliest detectable DF anomalies  (e.g.  monozygotic twins, conjoined twins and teratomas).
– DF that emerge after blastogenesis (formation of the body axis) are generally symmetric  (e.g. ocular globes) while others are not (e.g. lungs, liver, etc).
– A generalized asymmetry is hemi-hypertrophy and hemi-atrophy.
– DF anomalies can result in regeneration, repair, agenesis, aplasia, hypoplasia, dysplasia, neoplasia,  atrophy, malformation, and deformation. 
–  Identical malformations can result from multiple different causes  phenocopies – e.g. holoprosencephaly  due to a variety of chromosomal anomalies and other teratogens.
– Dysmorphic impacts on an early DF (e.g. neural tube) can result in a cascade (sequence) of derivative malformations (e.g. anencephaly, spina bifida).
– A single cause can impact a single or multiple DF (e.g. syndrome – see associations*)
– Anomalies in a DF can induce anomalies in other DFs (associations*)
– Multiple causes can impact a DF and result in identical anomalies (phenocopies)
– Anomalies of a single DF can give rise of a cascade (sequence) of anomalies (e.g. neural tube anomalies can manifest as anencephaly, spina bifida or both)
– External factors (mainly physical-mechanical) can alter DF morphogenesis (deformations)

The above notions incorporate concepts from comparative anatomy, embryology, phylogeny, experimental embryology and teratology, as well as genetics.
* Association among specialists tends to denote “syndromes” of unknown etiology.